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Intraosseous Vascular Access Clinical Evidence

Worldwide, the intraosseous route’s safety and effectiveness is recognized as a standard in vascular access. A substantial body of evidence in the medical literature supports outcomes facilitated with intraosseous access. Articles describing EZ-IO pre-clinical and clinical studies, published in respected peer-reviewed clinical journals in 6 languages, support the clinical effectiveness of our technologies and provide the evidence-based data expected by healthcare professionals.

Intraosseous Vascular Access Bibliography

Download a comprehensive bibliography of articles describing IO access (regardless of device type or brand name), organized in categories including pharmacokinetics, clinical studies, case studies, guidelines, intraosseous devices, pediatrics, and complications.

EZ-IO Bibliography1

Download an annotated bibliography that lists over 80 articles describing the EZ-IO.

For more information on these clinical studies, abstracts and articles, please contact Vidacare Customer Service at 1-866-479-8500.


  1. The majority of these references were written by independent clinicians not affiliated with Vidacare Corporation. While the articles support intraosseous vascular access indications, claims and applications of EZ-IO, readers should consult a physician and product labeling for proper indications, contraindications, warnings and precautions for EZ-IO prior to use.